The past two weeks my tour of duty has taken me back to the bedrock of human health research in Kenya. That is where my medical practice and research began quarter of a decade ago. I looked forward to linking up with old friends in the field of malaria, Tuberculosis and HIV research care and treatment. The reality in terms of knowledge has shifted massively, however, the disease burden still remain high. While there have been major scientific breakthroughs, this has not translated directly into new treatments available to patients.